Friday, January 4, 2008

In a biological sense, Why does high cholesterol levels make humans susceptible to heart disease


In a biological sense, Why does high cholesterol levels make humans susceptible to heart disease?
Please somebody help me with this!!!!
Biology - 6 Answers
Random Answers, Critics, Comments, Opinions :
1 :
A heart attack occurs when blood flow to a section of heart muscle becomes blocked. If the flow of blood isn’t restored quickly, the section of heart muscle becomes damaged from lack of oxygen and begins to die.
2 :
it blocks the artery hence blood supply
3 :
..it bLocks the arteries that carRies bLood.. ..to the heart.. ..that's why it causes the bLood to kinda stop fLowing.. ..i think that's it..
4 :
A high blood-cholesterol level (over 6 m.mol per litre or 238 mg per 100 ml) is undesirable as there may be a correlation between a high blood cholesterol and atheroma, the form of arterial degenerative disease associated with coronary thrombosis and high blood-pressure. This is well exemplified in diabetes mellitus and hypothyroidism, two diseases in which there is high blood cholesterol, sometimes going as high as 20 m.mol per litre; patients with these diseases are particularly prone to arterial disease. There is also a familial disease known as hypercholesterolemia, in which members of affected families have a blood cholesterol of around 18 m.mol per litre, or more, and are particularly liable to premature degenerative disease of the arteries. Medical laboratories now subdivide total cholesterol measurement into several components, including LDL ("bad") cholesterol, which is directly linked to heart disease, and HDL ("good") cholesterol, which is protective. The relative amount of HDL to LDL is more important than total cholesterol. For example, it is possible for someone with very high HDL to be at relatively low risk for heart disease even with total cholesterol above 200. Evaluation of changes in cholesterol requires consultation with a healthcare professional and should include measurement of total serum cholesterol, as well as HDL and LDL cholesterol. ..
5 :
when the cholesterol rises in your blood the endothelium lining the arteries are damaged. the endothelium lining the arteries can be damaged due to smoking, diabetes and high blood pressure and also due to high cholesterol in the blood. when the endothelium is damaged the cholesterol is deposited in the arteries supplying the heart. there is formation of plaque. these plaque grow and block the arteries, there are stable and unstable plaques. the stable plaques decreases the blood supply to the heart causing narrowing of the arteries. but the unstable plaque rupture and blood clotting occurs which finally blocks the arteries. There are LDL(low density lipoproteins) and HDL(high density lipoproteins). this LDL cholesterol carries the cholesterol from the liver to the tissues and HDL carries the cholesterol from the tissues to the liver, the liver can finally excreate the cholesterol through the bile. hence HDL is a good cholesterol and LDL is bad cholesterol.
6 :
Because high cholesterol level makes its deposition in the blood vessels being insoluble in water. Accumulation of cholesterol makes poor blood flow in the vessels. Therefore, heart has to pump blood with greater pressure,which ultimately results in high blood pressure & other cardio vascular disorders